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Biotech & LongevityRank #6 · 2026-W30

Programmable Protein Circuits for Cell-State Computation

arXiv:2502.04153

L. Nguyen, R. Alvarez, J. Kim

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Modular protein logic in mammalian cells moves synthetic biology beyond slow genetic programs toward post-transcriptional sense-and-respond control.

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We design modular protein logic circuits that perform multi-input cellular computations in mammalian cells, enabling sense-and-respond therapeutic programs with layered feedback and memory.