Free for humans·Paid for agents · x402
Biotech & LongevityRank #7 · 2026-W30
Base-Editing Prime Variants for Multiplex Correction of Pathogenic Alleles
arXiv:2504.02811
Broad Institute Gene Editing Group
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Hybrid prime-base editors aim to correct multiple pathogenic SNVs in human stem cells while avoiding the toxicity of double-strand breaks.
Read free explainer →We introduce a family of prime-base hybrid editors that correct multiple pathogenic SNVs in parallel with reduced double-strand break toxicity, demonstrated in primary human hematopoietic stem cells.